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Hyperthermic Treatment of Intraocular Tumors
Paul T. Finger, MD;
Samuel Packer, MD;
Paul P. Svitra, BA;
Robert W. Paglione, MSEE;
Jeremy Chess, MD;
Daniel M. Albert, MD
Arch Ophthalmol. 1984;102(10):1477-1481.
Abstract
• A 5.8-gigahertz (GHz) ophthalmic microwave applicator was used to treat choroidal melanoma (Greene strain) in rabbits. High-frequency electromagnetic radiation provides a favorable dose distribution to induce local hyperthermia in the treatment of intraocular tumors. Heating of the neoplasm, while sparing normal ocular structures, is best accomplished by a transscleral approach. A hyperthermia plaque is placed on the sclera at the base of the intraocular tumor. Contact (resistive) heating and electromagnetic radiation (radiofrequency and microwave) are best suited to a plaque technique. The advantages of electromagnetic heat induction, as compared with contact heating, are twofold: the depth of hyperthermic penetration can be modulated by frequency selection, and the tissues with low water content (sclera) remain relatively unaffected by microwaves. The 5.8-GHz ophthalmic microwave applicator satisfies the requirements for local hyperthermic treatment of intraocular tumors.
Author Affiliations
From the Medical Research Center, Brookhaven National Laboratory, Upton, NY (Drs Finger and Packer and Mr Svitra); the David Sarnoff Research Center, RCA Laboratories, Princeton, NJ (Mr Paglione); and the Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston (Drs Chess and Albert).
Footnotes
Accepted for publication March 26, 1984.
Reprint requests to the Ophthalmology Department, Manhattan Eye, Ear, and Throat Hospital, 210 E 64th St, New York, NY 10021 (Dr Finger).
This investigation was supported by the US Department of Energy contract DE-AC02-76CH0016.
Joseph Gatz provided electronics assistance, Dennis Greenberg performed laboratory tests, and William Marin, Jr, provided photomicrographs assistance (all of Brookhaven National Laboratory, Upton, NY). Fred Sterzer, PhD (RCA Laboratories, Princeton, NJ), Andre Szechter, PhD (St Vincent's Hospital, New York), Josef Mendecki, PhD (Montefiore Hospital, Bronx, NY), Robert McAfee, PhD (Veterans Hospital, New Orleans), William Hart, MD (Tulane Medical Center, New Orleans), and Robert Gordon, MD (Tulane Medical Center), provided valuable guidance.
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