Radiation Retinopathy After Orbital Irradiation for Graves' Ophthalmopathy

doi:10.1001/archopht.1984.01040031193016

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Vol. 102 No. 10, October 1984

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Radiation Retinopathy After Orbital Irradiation for Graves' Ophthalmopathy

James L. Kinyoun, MD; Robert E. Kalina, MD; Scot A. Brower, MD; Richard P. Mills, MD; Roger H. Johnson, MD

Arch Ophthalmol. 1984;102(10):1473-1476.

Abstract

• Recent reports indicate that orbital irradiation forGraves' ophthalmopathy is sometimes beneficial, particularlyfor dysthyroid optic neuropathy, and is not associated withserious complications. We are aware, however, of four patientswho were found to have radiation retinopathy after orbital irradiationfor Grave's ophthalmopathy. All four patients have decreasedcentral acuity, and three of the four are legally blind in oneor both eyes. Computer reconstruction of the dosimetry, basedon computed tomography and beam profiles, shows that errorsin dosage calculations and radiotherapy technique probably accountfor the radiation retinopathy in three of the four patients.Radiotherapy for Graves' ophthalmopathy should be administeredonly by competent radiotherapists who are experienced in thetreatment of this disease. Similar errors in dosage calculationsand treatment techniques may account for other reports of radiationretinopathy after reportedly safe dosages.

Author Affiliations

From the Department of Ophthalmology, University of Washington School of Medicine, Seattle.

Footnotes

Accepted for publication April 18, 1984.

Reprint requests to Department of Ophthalmology RJ-10, Universityof Washington, Seattle, WA 98195 (Dr Kinyoun).

This investigation was supported in part by an unrestrictedgrant from Research to Prevent Blindness, Inc.

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