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Radiation Retinopathy After Orbital Irradiation for Graves' Ophthalmopathy
James L. Kinyoun, MD;
Robert E. Kalina, MD;
Scot A. Brower, MD;
Richard P. Mills, MD;
Roger H. Johnson, MD
Arch Ophthalmol. 1984;102(10):1473-1476.
Abstract
• Recent reports indicate that orbital irradiation for Graves' ophthalmopathy is sometimes beneficial, particularly for dysthyroid optic neuropathy, and is not associated with serious complications. We are aware, however, of four patients who were found to have radiation retinopathy after orbital irradiation for Grave's ophthalmopathy. All four patients have decreased central acuity, and three of the four are legally blind in one or both eyes. Computer reconstruction of the dosimetry, based on computed tomography and beam profiles, shows that errors in dosage calculations and radiotherapy technique probably account for the radiation retinopathy in three of the four patients. Radiotherapy for Graves' ophthalmopathy should be administered only by competent radiotherapists who are experienced in the treatment of this disease. Similar errors in dosage calculations and treatment techniques may account for other reports of radiation retinopathy after reportedly safe dosages.
Author Affiliations
From the Department of Ophthalmology, University of Washington School of Medicine, Seattle.
Footnotes
Accepted for publication April 18, 1984.
Reprint requests to Department of Ophthalmology RJ-10, University of Washington, Seattle, WA 98195 (Dr Kinyoun).
This investigation was supported in part by an unrestricted grant from Research to Prevent Blindness, Inc.
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