Goblet Cell Density in Ocular Surface Disease: A Better Indicator Than Tear Mucin

doi:10.1001/archopht.1983.01040020286025

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Vol. 101 No. 8, August 1983

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Goblet Cell Density in Ocular Surface Disease

A Better Indicator Than Tear Mucin

Shigeru Kinoshita, MD; Timothy C. Kiorpes, PhD; Judith Friend, MA; Richard A. Thoft, MD

Arch Ophthalmol. 1983;101(8):1284-1287.

Abstract

• Mucinlike glycoprotein from tears and conjunctival gobletcell densities were determined in normal subjects and in patients.The results indicated that although there was a statisticallysignificant decrease, a substantial amount of mucinlike glycoproteinwas present in tears from patients with ocular cicatricial pemphigoid(OCP), radiation keratitis, and corneal anesthesia. In the samepatients, the goblet cell count was profoundly decreased inOCP and radiation keratitis, well out of proportion to the modestfall in mucinlike glycoprotein. This indicated that the tearmucin content shows minimal variation over a great variationin goblet cell density, suggesting that while moderate mucindeficiency may be associated with surface abnormalities, suchmucin deficiency may not be the only cause of the ocular surfaceepithelial problems characteristic of these diseases. In addition,it is proposed that the goblet cell content of the conjunctivais a sensitive indicator of primary ocular surface disease.

Author Affiliations

From the Cornea Service, Massachusetts Eye and Ear Infirmary, and the Department of Cornea Research, Eye Research Institute of Retina Foundation, Boston.

Footnotes

Accepted for publication Aug 31, 1982.

Reprint requests to Ocular Surface Laboratory, 243 Charles St,Boston, MA 02114 (Dr Thoft).

This investigation was supported in part by research grantsEY01830 and EY03061 from the National Eye Institute and in partby the Lions Eye Research Fund Inc.

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