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Topical Nylidrin and Aqueous Humor Dynamics in Rabbits and Monkeys
Louis Sobel, MD;
Janet B. Serle, MD;
Steven M. Podos, MD;
Theodore Krupin, MD;
Gary S. Chubak, MD;
Michael E. Yablonski, MD, PhD;
Colette Severin, MS
Arch Ophthalmol. 1983;101(8):1281-1283.
Abstract
• Topical administration of nylidrin hydrochloride lowered intraocular pressure in both albino rabbits and cynomologus monkeys. The maximum decrease occurred two hours following drug application and was unilateral. The response lasted four hours in monkeys and at least six hours in rabbits. Outflow facility, episcleral venous pressure, and aqueous humor flow measured by fluorophotometry were unaltered in both species. In rabbits in the treated eyes, ocular blood flow was increased, and anterior and posterior chamber ascorbate concentrations were unchanged. The mechanism of IOP reduction appears to be increased aqueous humor outflow via uveoscleral outflow routes that are not pressure dependent.
Author Affiliations
From the Department of Ophthalmology, Mount Sinai School of Medicine, City University of New York.
Footnotes
Accepted for publication July 30, 1982.
Reprint requests to Mount Sinai School of Medicine, 1 Gustave L. Levy PI, New York, NY 10029 (Dr Podos).
This study was supported in part by research grants EY 03651, EY 01867, EY 07014, and EY 00004 and research career development award EY 00082 (Dr Krupin) from the National Institutes of Health and by an unrestricted grant from Research to Prevent Blindness, Inc.
Barnes-Hind Pharmaceuticals, Inc, supplied the nylidrin and partial support for the rabbit studies. Miles Galin, MD, brought the drug to our attention.
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