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Neuro-ophthalmologic Manifestations

Joel M. Weinstein, MD; Helena Chui, MD; Stephen Lane, MD; James Corbett, MD; Javad Towfighi, MD

Arch Ophthalmol. 1983;101(8):1217-1220.

Abstract
• Two patients with severe bronchial asthma, hypereosinophilia, and peripheral neuropathy were initially observed with neuro-ophthalmologic signs and symptoms that included amaurosis fugax, superior oblique palsy, ischemic optic neuropathy, and scattered areas of retinal infarction. Clinical investigation led to the diagnosis of Churg-Strauss syndrome (allergic granulomatous angiitis). As in other collagen vascular diseases, ocular signs or symptoms may occasionally be the most prominent manifestation of the disease. Recognition of this systemic disorder by the ophthalmologist may minimize systemic and ocular complications.

Author Affiliations
From the Divisions of Ophthalmology (Drs Weinstein and Lane) and Neurology (Dr Weinstein) and the Department of Pathology (Dr Towfighi), Pennsylvania State University, Hershey; and the Department of Neurology (Drs Corbett and Chui), University of Iowa School of Medicine, Iowa City. Dr Chui is now with the University of Southern California School of Medicine, Los Angeles.

Footnotes
Accepted for publication June 2, 1982.

Reprint requests to Division of Ophthalmology, The Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033 (Dr Weinstein).

Peter Bosch, MD, University of Iowa, performed the muscle and nerve biopsy and the single fiber and axonal studies in case 2.

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