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A Histopathologic Study

John C. Merriam, MD; Leo T. Chylack, Jr, MD; Daniel M. Albert, MD

Arch Ophthalmol. 1983;101(7):1085-1092.

Abstract
• A young girl with early-onset pauciarticular juvenile rheumatoid arthritis suffered from recurrent severe bilateral iridocyclitis. Despite intensive medical therapy, she gradually lost all useful vision and ultimately required bilateral enucleation at the age of 10 years for control of pain and photophobia. Histopathologic study of the eyes revealed in the iris and ciliary body a dense inflammatory infiltrate composed principally of plasma cells, as well as angle closure, a dense cyclitic membrane, retinal detachment, cystoid macula, and optic atrophy. Immunoperoxidase stains showed little immunoglobulin within or around the plasma cells within the ciliary body, although strong reactions for IgG and - and -light chains were seen in other parts of the eyes.

Author Affiliations
From the Howe Laboratory of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary (Drs Merriam, Chylack, and Albert), and the Brigham and Women's Hospital (Dr Chylack), Boston. Dr Merriam is now at the Francis I. Proctor Foundation for Research in Ophthalmology, University of California, San Francisco.

Footnotes
Accepted for publication July 19, 1982.

Reprint requests to the Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114 (Dr Chylack).

This study was supported by the Arthritis Foundation, the Brigham Surgical Group Foundation, the Gebbie Foundation, the New England Peabody Home Foundation, and grant AM25252 from the National Institutes of Health.

Bruce Kaynor prepared the immunoperoxidase stains. Harold Dommu prepared the photomicrographs. Diane Mahoney typed the manuscript. David N. Glass, MD, Department of Medicine, Harvard Medical School, reviewed the manuscript.

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