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Kathleen Phillips, MD; Robert Arffa, MD; Charles Cintron, PhD; Jeannette Rose; David Miller, MD; Claire L. Kublin; Kenneth R. Kenyon, MD

Arch Ophthalmol. 1983;101(4):640-643.

Abstract
• Albino rabbits were treated four or six times daily with 1% prednisolone acetate, 1% medroxyprogesterone acetate, or a control vehicle, after one of three conditions. First, after 3-mm linear perforating stromal incisions; drugs were given for seven days, and wound bursting strength was determined. Prednisolone suppressed wound tensile strength by 20%; medroxyprogesterone suppressed it by 11%. Second, after trephination, drug administration for 14 days decreased collagen formation in the scar buttons by 43% in the prednisolone-treated group and 39% in the medroxyprogesterone-treated group. Third, after thermal burns; when drug application followed the burn immediately, deep ulceration or perforation developed in 85% of the controls, in none of the prednisolone-treated group, and in 17% of the medroxyprogesterone-treated group. When drug delivery was withheld until day 6, severe ulceration developed in 44% of both groups. In both experiments, stromal neovascularization was markedly suppressed by prednisolone, but only moderately decreased by medroxyprogesterone.

Author Affiliations
From the Department of Cornea Research, Eye Research Institute of Retina Foundation (Drs Phillips, Cintron, and Kenyon and Mss Rose and Kublin), Department of Ophthalmology, Beth Israel Hospital (Drs Arffa and Miller), and the Department of Ophthalmology, Harvard Medical School (Drs Phillips, Arffa, Cintron, Miller, and Kenyon), Boston.

Footnotes
Accepted for publication May 3, 1982.

Reprint requests to Library, Eye Research Institute of Retina Foundation, 20 Staniford St, Boston, MA 02114 (Dr Cintron).

This study was supported by grant EY-01199 from the National Eye Institute (Dr Cintron); National Institutes of Health (NIH) Academic Investigator Award EY-00156 (Dr Kenyon); NIH grant EY03967 (Dr Kenyon); a grant-in-aid from Fight for Sight, Ine (Dr Kenyon); the James S. Adams Research Award from Research to Prevent Blindness (Dr Kenyon); and the Massachusetts Lions Eye Resarch Fund, Inc.

The Pharmacy of the Massachusetts Eye and Ear Infirmary, Boston, provided pharmacological preparations. The Upjohn Company, Kalamazoo, Mich, provided the medroxyprogesterone acetate.

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