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Congenital Glaucoma and Other Ocular Abnormalities Associated With Pericentric Inversion of Chromosome 11
Warren L. Broughton, MD;
Kenneth N. Rosenbaum, MD;
George R. Beauchamp, MD
Arch Ophthalmol. 1983;101(4):594-597.
Abstract
• Pericentric inversion of chromosome 11 occurred in consecutive generations of family members with congenital glaucoma. Affected persons were characterized by unilateral or bilateral congenital glaucoma, bilateral corneal disease, and a lack of appreciable dysmorphism. Previous reports of inversions of chromosome 11 are rare, and no ocular abnormalities have been noted. Chromosomal abnormalities may be the cause of some forms of congenital glaucoma and should be included in the genetic heterogeneity of this disease.
Author Affiliations
From the Department of Ophthalmology, National Naval Medical Center, Bethesda, Md (Dr Broughton), and the Children's Hospital National Medical Center, Washington, DC (Drs Rosenbaum and Beauchamp). Dr Broughton is now with the Naval Regional Medical Center, San Diego.
Footnotes
Accepted for publication April 26, 1982.
The opinions and assertions contained herein are those of the authors and are not to be construed as official or as representing those of the Bureau of Medicine and Surgery of the Department of the Navy or of the Naval Service at large.
Reprint requests to Naval Regional Medical Center, San Diego, CA 92134 (Dr Broughton).
Marshall M. Parks, MD, performed the goniotomy on the proband and referred the patient to us. Walter Stark, MD, examined the proband in consultation.
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ABSTRACT
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