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Multiple-Drop Study of Topically Applied 1%  9-Tetrahydrocannabinol in Human Eyes
Walter M. Jay, MD;
Keith Green, PhD
Arch Ophthalmol. 1983;101(4):591-593.
Abstract
• Twenty-eight male volunteers were given either 1%  9-tetrahydrocannabinol 9-THC) or vehicle alone (light mineral oil). They used the medication four times per day for one week. Five volunteers, four of which used vehicle alone, discontinued the study because of burning sensation and lid swelling. In the 23 volunteers who completed the study, there was no difference in intraocular pressure between eyes treated with 1% 9-THC and controls.
Author Affiliations
From the Departments of Ophthalmology (Drs Jay and Green) and Physiology (Dr Green), Medical College of Georgia, Augusta, and the Veterans Administration Medical Center, Augusta, Ga (Drs Jay and Green).
Footnotes
Accepted for publication April 12, 1982.
Reprint requests to Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912 (Dr Jay).
This study was supported in part by research grants EY01590 from the National Eye Institute (Dr Jay) and DA01214 from the National Institute on Drug Abuse (Dr Green).
James L. Olsen, PhD, University of North Carolina, Chapel Hill, supplied the vehicle used in these studies.
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