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I. Clinical Study

Lawrence W. Hirst, MD; Douglas A. Jabs, MD; Peter J. Tutschka, MD; W. Richard Green, MD; George W. Santos, MD

Arch Ophthalmol. 1983;101(4):580-584.

Abstract
• A prospective study of 45 patients undergoing bone marrow transplantation included full ocular examination and pretransplant and posttransplant conjunctival biopsies. The major finding was the development of a severe keratoconjunctivitis sicca syndrome that developed in 20 of the 45 patients and closely correlated with the occurrence of acute graft-v-host disease (GVHD). An acute pseudomembranous conjunctivitis in the fulminant stage of acute GVHD developed in six patients. A further ten patients made up a retrospective assessment of bone marrow transplantation and confirmed these clinical findings.

Author Affiliations
From the Wilmer Ophthalmological Institute (Drs Hirst, Jabs, and Green), the Department of Pathology (Dr Green), and the Bone Marrow Transplant Unit, Oncology Center (Drs Tutschka and Santos), Johns Hopkins Medical Institutions, Baltimore. Dr Hirst is now with Bethesda Eye Institute, St Louis University.

Footnotes
Accepted for publication May 3, 1982.

Read in part before the meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Fla, April 27, 1981.

Reprint requests to Bethesda Eye Institute, St Louis University, 3655 Vista Ave, St Louis, MO 63110 (Dr Hirst).

This investigation was supported in part by Public Health Service research grant EY 02476 (Dr Hirst), NIH-NCI grant CA 15396 (Dr Santos), EM core grant EY 01765, and computer core grant 2 P30 EY 01765.

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