 |
|
Increased Tear Evaporation in Eyes With Keratoconjunctivitis Sicca
Maurizio Rolando, MD;
Miguel F. Refojo, DSc;
Kenneth R. Kenyon, MD
Arch Ophthalmol. 1983;101(4):557-558.
Abstract
• The terms dry eye and keratoconjunctivitis sicca (KCS) imply a condition of highly reduced or absent tear film that often is not clinically demonstrable despite the presence of other signs and symptoms. In 52 patients with KCS symptoms, either with or without tear volume reduction as measured by Schirmer's basic secretion test, we found a statistically significant increase in water evaporation rate from the tear film when compared with normal subjects. Such an increased evaporation rate might account for the tear hypertonicity known to be associated with KCS and postulated to be responsible for ocular surface damage. Thus, we propose to identify this group of paradoxically wet "dry eyes" as a "syndrome of increased tear evaporation", which better describes the pathogenesis of the ocular condition.
Author Affiliations
From the Eye Research Institute of Retina Foundation (Drs Rolando, Refojo, and Kenyon); the Cornea Service, Massachusetts Eye and Ear Infirmary (Dr Kenyon); and the Department of Ophthalmology, Harvard Medical School (Drs Refojo and Kenyon), Boston.
Footnotes
Accepted for publication May 3, 1982.
Reprints to Eye Research Institute of Retina Foundation, 20 Staniford St, Boston, MA 02114 (Dr Refojo).
This work was supported in part by the following: a Rotary Foundation Educational Award for International Understanding (Dr Rolando), National Institutes of Health grant EY00327 (Dr Refojo), and grant EY03967 and the Research to Prevent Blindness James S. Adams Award (Dr Kenyon).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
The Interblink Interval I: The Relationship between Sensation Intensity and Tear Film Disruption
Varikooty and Simpson
IOVS 2009;50:1087-1092.
ABSTRACT
| FULL TEXT
Thinning Rate of the Precorneal and Prelens Tear Films
Nichols et al.
IOVS 2005;46:2353-2361.
ABSTRACT
| FULL TEXT
Aquaporin-Dependent Water Permeation at the Mouse Ocular Surface: In Vivo Microfluorimetric Measurements in Cornea and Conjunctiva
Levin and Verkman
IOVS 2004;45:4423-4432.
ABSTRACT
| FULL TEXT
Tear Evaporation Dynamics in Normal Subjects and Subjects with Obstructive Meibomian Gland Dysfunction
Goto et al.
IOVS 2003;44:533-539.
ABSTRACT
| FULL TEXT
Assessment of Meibomian Gland Function in Dry Eye Using Meibometry
Yokoi et al.
Arch Ophthalmol 1999;117:723-729.
ABSTRACT
| FULL TEXT
Effects of Ocular Surface Area and Blink Rate on Tear Dynamics
Tsubota and Nakamori
Arch Ophthalmol 1995;113:155-158.
ABSTRACT
Dry Eyes and Video Display Terminals
Tsubota and Nakamori
NEJM 1993;328:584-584.
FULL TEXT
|
