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Akitoshi Yoshida, MD; Gilbert T. Feke, PhD; Julian Morales-Stoppello, MD; Gail D. Collas, MS; Douglas G. Goger; J. Wallace McMeel, MD

Arch Ophthalmol. 1983;101(2):225-227.

Abstract
• Alterations in retinal blood flow during the progression of diabetic retinopathy were studied using the dye-dilution technique. Mean fluorescein circulation times were measured in retinal arteriovenous segments with a two-point fluorophotometer in 48 diabetic patients and 20 normal controls. Monochromatic fundus photographs were used to determine vessel diameters. Segmental blood flow (SBF) increased with the progression of background diabetic retinopathy. In patients with distinct capillary closure, SBF was significantly higher than normal values.

Author Affiliations
From the Eye Research Institute, Retina Foundation (Drs Yoshida, Feke, Stopello, and McMeel, Ms Collas, and Mr Goger), and the Retina Associates (Dr McMeel), Boston. Dr Morales-Stoppello is now with Universidad Central de Venezuela, Caracas.

Footnotes
Accepted for publication March 10, 1982.

Reprint requests to Library, Eye Research Institute, 20 Staniford St, Boston, MA 02114 (Dr Feke).

This work was supported by National Eye Institute grant ROI EY02164.

Glenn J. Green, MD, and Sven-Erik Bursell, PhD, provided helpful suggestions.

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