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  Vol. 101 No. 12, December 1983 TABLE OF CONTENTS
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A Prognostic Factor Study of Disease-Free Interval and Survival Following Enucleation for Uveal Melanoma

Johanna M. Seddon, MD; Daniel M. Albert, MD; Philip T. Lavin, PhD; Nancy Robinson

Arch Ophthalmol. 1983;101(12):1894-1899.


Abstract



• Prognostic indicators of uveal melanoma disease-free interval and survival following enucleation were evaluated for 267 patients. The median follow-up time was 17 years. Analysis involved Kaplan-Meier survival curves based on time to tumor-related deaths and multivariate proportional hazards analysis, which provides an estimate of the "force of mortality." Prognostic indicators considered included demographic, clinical, and histopathological factors. Cell type was classified according to the number of epithelioid cells present per high-power field (HPF) on light microscopy. Various classifications of size of the tumor were compared for prognostic value. The five leading predictors of survival in order of importance were as follows: (1) number of epithelioid cells per HPF, (2) largest dimension of the tumor, (3) location of the anterior margin of the tumor, (4) invasion to the line of transection, and (5) degree of pigmentation. Risk categories for survival were constructed based on the three leading prognostic factors.



Author Affiliations



From the Retina Service and the David G. Cogan Eye Pathology Laboratory, Massachusetts Eye and Ear Infirmary, and the Department of Ophthalmology, Harvard Medical School, Boston (Drs Seddon and Albert and Ms Robinson), and the Division of Biostatistics and Epidemiology, Sidney Farber Cancer Institute, Boston (Dr Lavin).


Footnotes



Accepted for publication Feb 7, 1983.

Presented to the Association for Research in Vision and Ophthalmology, Sarasota, Fla, May 4, 1982.

Reprint requests to Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114 (Dr Seddon).

This study was supported in part by grants 5 F32 EY05507 (Dr Seddon) and 5 ROI EY01917 (Dr Albert) from the National Eye Institute Bethesda, Md, grant CA-06516 from the National Cancer Institute (Dr Lavin), Bethesda, Md, and grant 5 S07 PR05526, Biomédical Research Support Grant, from the Sidney Farber Cancer Institute, Boston (Dr Lavin).

William Fine, MS, provided follow-up procedures and Ellen Hertzmark, MA, helped with statistical analysis.



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