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Allan J. Flach, MD, PharmD; Bernard J. Dolan, OD, MS; Bonnie Sudduth, RN, NP; Joan Weddell

Arch Ophthalmol. 1983;101(10):1554-1556.

Abstract
• Amiodarone hydrochloride is a benzofurane derivative used for cardiac abnormalities. Its use is commonly associated with an asymptomatic keratopathy. Although lipid deposits have been observed with the electron microscope in the lens epithelium of one patient with a history of amiodarone therapy, lens opacities have not been reported in patients using this drug. Visually inconsequential, anterior subcapsular lens opacities in seven of 14 patients using moderate to high doses of amiodarone who were examined at the Veterans Administration Hospital in San Francisco are reviewed.

Author Affiliations
From the Department of Ophthalmology, University of California School of Medicine (Dr Flach and Ms Weddell), and Veterans Administration Hospital (Drs Flach and Dolan and Ms Sudduth), San Francisco.

Footnotes
Accepted for publication Feb 4, 1983.

Reprint requests to 4150 Clement St (112A), San Francisco, CA 94121 (Dr Flach).

This investigation was supported in part by grant EY-02141 from the National Institutes of Health and The Burroughs Wellcome Fund.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Amiodarone-Induced Lens Opacities: An 8-Year Follow-up Study
Flach and Dolan
Arch Ophthalmol 1990;108:1668-1669.
ABSTRACT