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Chi Chao Chan, MD; W. Richard Green, MD; Zenaida C. de la Cruz; Argye Hillis, PhD

Arch Ophthalmol. 1982;100(9):1459-1463.

Abstract
• Osteogenesis imperfecta is a rare, inherited, connective-tissue disorder. The three main signs of this disease are multiple bone fractures, blue scleras, and deafness (osteosclerotic type). In our research, only a few reports of the morphologic studies of the eyes of patients with osteogenesis imperfecta were found. This report describes the ocular histopathologic condition of four cases of osteogenesis imperfecta congenita, with emphasis on the ultrastructural characteristics of the collagen in the cornea and sclera.

Author Affiliations
From the Eye Pathology Laboratory, Wilmer Ophthalmological Institute (Drs Chan, Green, and Hills and Ms de la Cruz), and the Departments of Pathology (Drs Chan and Green and Ms de la Cruz) and Biostatistics (Dr Hillis), The Johns Hopkins Medical Institutions, Baltimore.

Footnotes
Accepted for publication July 17, 1981.

Reprint requests to Eye Pathology Laboratory, The John Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21205 (Dr Green).

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