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HLA Antigens in Stevens-Johnson Syndrome With Ocular Involvement
Bartly J. Mondino, MD;
Stuart I. Brown, MD;
Albert W. Biglan, MD
Arch Ophthalmol. 1982;100(9):1453-1454.
Abstract
• Fifteen white patients and three black patients with Stevens-Johnson syndrome (SJS) with ocular involvement had HLA typing performed. The HLA-Bw44 antigen was found to have an increased frequency of 66.7% in white patients with SJS with ocular involvement, which was statistically significant when compared with a frequency of 20.4% in the white control population. The results of this study suggest that there is an immunogenetic susceptibility to the development of SJS with ocular manifestations in white patients.
Author Affiliations
From the University of Pittsburgh School of Medicine (Drs Mondino, Brown, and Biglan); the Department of Ophthalmology, Eye & Ear Hospital, Pittsburgh (Drs Mondino and Brown); and the Children's Hospital of Pittsburgh (Dr Biglan). Dr Mondino is now with the UCLA School of Medicine, Los Angeles.
Footnotes
Accepted for publication Aug 28, 1981.
Reprint requests to Jules Stein Eye Institute, UCLA School of Medicine, The Center for Health Sciences, Los Angeles, CA 90024 (Dr Mondino).
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