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Oral and Topical Treatment of Experimental Herpes Simplex Iritis With Bromovinyldeoxyuridine
Prabhat C. Maudgal, MD, DSc;
Walter Uyttebroeck, MD;
Erik De Clercq, MD, PhD;
Luc Missotten, MD, PhD
Arch Ophthalmol. 1982;100(8):1337-1340.
Abstract
• Oral treatment of rabbits with bromovinyldeoxyuridine ([E]-5-[2-bromovinyl]2'-deoxyuridine) at 10 or 100 mg/kg/day for four days significantly reduced the severity of herpes simplex iritis. This effect was not potentiated by the concomitant subconjunctival injection of sustained-action betamethasone. A significant reduction in the severity of herpetic iritis was also observed on topical application of bromovinyldeoxyuridine, and, in this regard, 0.5% bromovinyldeoxyuridine eyedrops proved significantly more efficacious than 1% trifluridine eyedrops.
Author Affiliations
From the Eye Research Laboratory, Ophthalmological Clinic (Drs Maudgal, Uyttebroeck, and Missotten); and the Rega Institute for Medical Research (Dr De Clercq), Leuven Catholic University, Leuven, Belgium.
Footnotes
Accepted for publication Sept 30, 1981.
Reprint requests to Eye Research Laboratory, Ophthalmological Clinic, A. Z. St Raphael, Kapucijnenvoer 7, B-3000 Leuven, Belgium (Dr Maudgal).
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