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Disposition of Topical Flurbiprofen in Normal and Aphakic Rabbit Eyes
Janet A. Anderson, PhD;
Chi Chu Chen, PhD;
Joao Brasil Vita, MD;
Martha Shackleton
Arch Ophthalmol. 1982;100(4):642-645.
Abstract
• In a study of the ocular absorption and elimination of a topically applied nonsteroidal anti-inflammatory drug (NSAID), flurbiprofen, the compound was well absorbed into rabbit ocular tissues and was highly concentrated in the rabbit cornea. In aphakic eyes, more drug penetrated to the vitreous and choroid-retina area than in normal rabbit eyes, although corneal concentrations were still high. No ocular metabolism of flurbiprofen could be detected, and the ocular route of application did not lead to any changes in blood elimination rates or metabolism when compared with intravenously injected drug. Currently, no NSAID is available for topical ocular use, and the development of such a drug is desirable for treatment of ocular inflammations, especially when long-term treatment is indicated.
Author Affiliations
From the Department of Ophthalmology, University of California, Irvine (Drs Anderson and Vita); and the Biochemistry Section, Pharmaceutical Sciences, Allergan Pharmaceuticals, Inc, Irvine, Calif (Drs Anderson and Chen and Ms Shackleton).
Footnotes
Accepted for publication July 7, 1981.
Read in part before the Association for Research in Vision and Ophthalmology, Orlando, Fla, May 4, 1980.
Reprint requests to Department of Ophthalmology, University of California, Irvine, CA 92717 (Dr Anderson).
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