 |
|
Amiodarone KeratopathyCorrelation to Dosage and Duration
Linda J. Kaplan, MD;
William E. Cappaert, MD
Arch Ophthalmol. 1982;100(4):601-602.
Abstract
• Amiodarone hydrochloride, a benzofurane derivative used for the treatment of cardiac arrhythmias, is known to cause a verticillate epithelial keratopathy, which has been classified into three stages. Patients receiving low dosages of 100 to 200 mg of amiodarone daily retain clear corneas or show stage 1 changes only, regardless of duration of treatment or total amount of substance ingested. Patients receiving higher dosages of 400 to 1,400 mg/day show stage 2 and 3 changes, depending on duration of treatment. This keratopathy progresses, even with reduced dosage; however, complete regression occurs once administration of medication is discontinued.
Author Affiliations
From the Division of Ophthalmology, Department of Surgery, Case Western Reserve University Hospitals, Cleveland (Dr Kaplan), and Cleveland Metropolitan General Hospital (Dr Cappaert).
Footnotes
Accepted for publication June 26, 1981.
Read in part before the Association for Research in Vision and Ophthalmology, Sarasota, Fla, April 28, 1981.
Reprint requests to Division of Ophthalmology, Cleveland Metropolitan General Hospital, 3395 Scranton Rd, Cleveland, OH 44109 (Dr Cappaert).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Papillopathy Caused by Amiodarone
Gittinger and Asdourian
Arch Ophthalmol 1987;105:349-351.
ABSTRACT
Amiodarone-Induced Lens Opacities
Flach et al.
Arch Ophthalmol 1983;101:1554-1556.
ABSTRACT
|
