Ocular neovascularization with retinal vascular occlusion. I. Association with experimental retinal vein occlusion
P. S. Virdi and S. S. Hayreh
Experimental occlusion of both major temporal retinal veins simultaneously
(in six eyes of cynomolgus monkeys) and of the central retinal vein (in one
rhesus monkey) produced a fall in intraocular pressure (hypotensive effect)
and neovascularization (NV) of the iris and, less frequently, of the optic
disc (vasogenic effect). The retinal changes (severity and extent of
retinopathy, retinal capillary leakage, and onset and extent of retinal
capillary obliteration) were correlated with the pattern of ocular NV and
hypotony. No direct correlation was seen between the retinal capillary
obliteration and the hypotensive or vasogenic effect. However, a
correlation was found between the retinal vascular leakage and the
development of ocular NV and hypotony. The pathogeneses of ocular NV and
hypotony in retinal vein occlusion are discussed in light of the findings
of this study.
