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Marwan M. Uwaydah, MD; Nabil Jabbour, MD; Sharbil Fahd, MD; Muhammad Jaafar, MD; Bishara M. Faris, MD

Arch Ophthalmol. 1982;100(2):329-330.

Abstract
• Intraocular penetration of moxalactam disodium, a new broad-spectrum oxa-β-lactam antibiotic, was studied in 18 patients undergoing cataract surgery. The antibiotic was administered in a 2-g single dose by intravenous drip during a 20-minute period. After 40 to 230 minutes, moxalactam aqueous humor concentrations ranged from 1.1 to 5.0 µg/mL (mean, 2.3 µg/mL). The ratio of aqueous humor concentrations to concomitant serum concentrations ranged from 1.6% to 9.8%. The achievable aqueous moxalactam concentrations were well above the minimum inhibitory concentrations of most Gram-negative enteric bacilli but not of Pseudomonas and staphylococci.

Author Affiliations
From the Departments of Microbiology (Dr Uwaydah), Medicine (Dr Uwaydah), and Ophthalmology (Drs Jabbour, Fahd, Jaafar, and Faris), American University of Beirut, Lebanon.

Footnotes
Accepted for publication March 19, 1981.

Reprint requests to American University Hospital, Beirut, Lebanon (Dr Uwaydah).

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