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Ocular Effects of Topical Administration of 9-Tetrahydrocannabinol in Man

Keith Green, PhD; Michael Roth, MD

Arch Ophthalmol. 1982;100(2):265-267.

Abstract
• ⁹-Tetrahydrocannabinol (THC) or vehicle alone was applied topically to one eye of normal paid volunteers. Ocular and systemic toxic effects and intraocular responses were measured in different series. Toxicity was limited to minor conjunctival injection that was of short (< 60 minutes) duration and occurred with both drug and vehicle alone. Subjective responses indicated a sensation of minor burning and/or tearing. No fall in intraocular pressure was found. A small (1 mm) but significant mydriasis occurred in both the treated eye and untreated eye and was not drug related. Single-drop administration of ⁹-THC did not, therefore, cause any significant ocular irritation or reduce IOP.

Author Affiliations
From the Departments of Ophthalmology (Drs Green and Roth) and Physiology (Dr Green), Medical College of Georgia, Augusta.

Footnotes
Accepted for publication April 17, 1981.

Reprint requests to Department of Ophthalmology, Box 3059, Medical College of Georgia, Augusta, GA 30912 (Dr Green).

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