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Por T. Hung, MD; Jui W. Hsieh, MD; George C. Y. Chiou, PhD

Arch Ophthalmol. 1982;100(2):262-264.

Abstract
• Ocular hypotensive actions of N-demethylated carbachol hydrochloride (DMC) were studied in patients with open angle glaucoma; 1% pilocarpine hydrochloride solution was used as a reference. Although 1% pilocarpine seemed to be slightly more potent than 6% and 9% DMC solutions, DMC solutions were devoid of the noticeable side effects produced by pilocarpine. In all cases, maximum ocular hypotensive actions were observed six hours after the single-drop medication and were determined as 4.2, 4.6, and 4.8 mm Hg with 6% DMC, 9% DMC, and 1% pilocarpine, respectively.

Author Affiliations
From the Department of Ophthalmology, National Taiwan University College of Medicine, Taipei (Drs Hung and Hsieh); and the Department of Medical Pharmacology and Toxicology, Texas A & M University College of Medicine, College Station (Dr Chiou).

Footnotes
Accepted for publication March 20, 1981.

Reprint requests to Department of Medical Pharmacology and Toxicology, Texas A & M University College of Medicine, College Station, TX 77843 (Dr Chiou).

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