You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 100 No. 2, February 1982 TABLE OF CONTENTS
  Archives
  •  Online Features
  ARTICLE
 This Article
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal

Bilateral diffuse melanocytic uveal tumors associated with systemic malignant neoplasms. A recently recognized syndrome

C. C. Barr, L. E. Zimmerman, V. T. Curtin and R. L. Font

Four cases of the simultaneous occurrence of bilateral diffuse melanocytic uveal tumors were studied by us. In each case, the patient had an associated systemic malignant neoplasm diagnosed by biopsy or at autopsy. There was no evidence of metastatic melanoma in any patient. Clinically, the patients experienced rapid loss of vision, and cataracts were usually present. Multiple pigmented and nonpigmented placoid iridic and choroidal nodules, as well as serous retinal detachment, frequently were noted. Histopathologically, the uveal tracts of both eyes were diffusely infiltrated by preponderantly benign-appearing nevoid or spindle-shaped cells. Areas of necrosis within the tumors and scleral involvement were commonly seen. We believe this constellation of findings constitutes a new syndrome in which there is a bilateral, diffuse proliferation of melanocytic cells throughout the uvea in association with a systemic malignant neoplasm.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Unilateral diffuse uveal melanocytic proliferation (DUMP)
Reddy and Finger
Br. J. Ophthalmol. 2007;91:1726-1727.
FULL TEXT  

Uveal and Cutaneous Involvement in Paraneoplastic Melanocytic Proliferation
Singh et al.
Arch Ophthalmol 2003;121:1637-1640.
FULL TEXT  

Noncontiguous Tumor Recurrence of Posterior Uveal Melanoma After Transscleral Local Resection
Kim et al.
Arch Ophthalmol 2002;120:1659-1664.
ABSTRACT | FULL TEXT  

Unilateral, Idiopathic Leopard-Spot Lesion of the Retinal Pigment Epithelium
Cohen et al.
Arch Ophthalmol 2002;120:512-516.
FULL TEXT  

Case 2-2002- A 58-Year-Old Woman with Unilateral Loss of Vision and Postmenopausal Bleeding
D'Amico and Dryja
NEJM 2002;346:189-195.
FULL TEXT  

Mushroom-Shaped Choroidal Melanocytoma Mimicking Malignant Melanoma
Robertson et al.
Arch Ophthalmol 2002;120:82-85.
FULL TEXT  

Multifocal Choroidal Malignant Melanoma: At Least 3 Melanomas in One Eye
Blumenthal and Pe'er
Arch Ophthalmol 1999;117:255-258.
ABSTRACT | FULL TEXT  

Pigmented uveal tumours in a transgenic mouse model
Kramer et al.
Br. J. Ophthalmol. 1998;82:953-960.
ABSTRACT | FULL TEXT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1982 American Medical Association. All Rights Reserved.