Amyloidosis of the vitreous. Fluorescein angiographic findings and association with neovascularization
D. J. Savage, C. A. Mango and B. W. Streeten
A case of primary systemic amyloidosis with bilateral asymmetric
involvement of the vitreous was followed up throughout a 45-month span,
during which two vitrectomy procedures were done on one eye. The
progressive nature of this disease was documented by serial fluorescein
angiograms and fundus photography. The amyloid seemed to be derived from
the retina, at small multifocal areas over arterioles and venules that were
otherwise clinically and angiographically normal in appearance. Follow-up
studies suggested that these focal deposits were actually preretinal, since
they disappeared after posterior vitrectomy. Peripheral neovascularization
was visible in this case, which has not previously been reported.
Amyloidosis of the vitreous can mimic numerous other diseases. Vitrectomy
can be effective in restoring visual acuity, although recurrence may be
rapid. The diagnosis is readily made by pathologic examination of the
vitreous aspirate.
