Axonal transport interruption and anatomy at the lamina cribrosa
R. L. Radius and B. Bade
Pressure-induced, focal axonal transport abnormalities were studied in 14
cat eyes by the examination of serial step-section tissue radioautogram.
Although the patterns of the transport interruption at the lamina cribrosa
varied from eye to eye, the temporal sectors of the nerve head were most
often involved by this abnormality. The anatomy at the lamina cribrosa was
studied in adjacent (6 micrometers) cross-sectional specimens. The
thickness of the extra-bundle trabeculae and the nerve fiber bundle
dimensions including the cross-sectional area and the number and the shape
(the ratio of the major and the minor axis diameters) of the laminar pores
were measured by computer-assisted perimeter analysis. There was no
correlation between the location of the transport interruption and any of
these anatomic measurements.
